paediatrics Brussels 17

Current COG Guidelines

Stage

Chemotherapy

Radiotherapy

Stage I-III, FA Stage I, DA

VCR, AMD and DOX (Regimen DD4A)

Abdominal/Flank RT

Stage IV, FA Stage II-IV, DA (with no measurable disease)

VCR,AMD, DOX, CPM, VP16, CARBO (Regimen UH-1)

Abdominal/Flank RT Lung RT if lung mets

Stage IV, CCSK Stage I-IV, RTK

Stage IV, DA (with measurable disease)

VCR, AMD, DOX, CPM, VP16, CARBO, IRINOTECAN VCR, AMD, DOX, CPM, VP16 (Regimen I)

Abdominal/Flank RT Lung RT if lung mets

Stage I-III CCSK

Abdominal/Flank RT except Stage I CCSK