paediatrics Brussels 17

RT for high risk localized RT

Studies

n

Dose

Fractionation

Volume

Relapse rate Local/metasta sis/both/total

Wolden et al. IJROBP 2000 Kushner et al. JCO 2001

99

21Gy

1.5Gy BID Extent of tumor at diagnosis + 3 cm + lymph nodes

10/45/55

Laprie et al. Cancer 2004

32

24 Gy or 34 Gy

1.5Gy/day

Preoperative volume + 2cm 0/0/1/1

Haas-kogan et al. IJROBP 2003

31

10 Gy TBI + 10 Gy or 20 Gy

2 Gy/Day

Preoperative volume + 2cm 22% failure rate

Bradfield et al. Cancer 2004

17

21 Gy +/- 9Gy

1.5 Gy/day

Preoperative volume + 2cm 1/6/0/7

Ducassou et al, Strahlen Onkol 2015

35

24 Gy or 34 Gy

1.5 Gy/day

Preoperative volume + 2cm 69% local control at 15 years

Casey et al, ASTRO 2016

246

21Gy

3%local failure at 5 years

1.5 Gy/day