paediatrics Brussels 17

Benefit of IMRT in UCNT : local control and survival (children)

N

Time of RT 5 y Local Control 5-y DFS

5-y OS

Laskhar, Int J Radiat Oncol Biol Phys 2008 CRT: 17 2003-2006 68.2% (2-y) IMRT : 19 84.2% (2-y) Qiu, J Cancer Res Clin Oncol2017 CRT: 74 2003-2013 88.3%

71.2% 76.1%

IMRT : 102

97.9%

85.7% 90.4%

Liu, Radiat Oncol 2014

CRT: 103 1990-2011 No difference

No difference

IMRT : 55

- No randomized study in childhood

- The most recent large retrospective study confirms the benefit in term of : - Local control : + 9% - Survival +14%