paediatrics Brussels 17

Moxon-Emre et al

Index No. Mean SE Comparison P Estimate SE Comparison P Estimate SE P Comparison P Estimate SE P Hydrocephalus .001 .24 .06

Yes 24 80.26 3.44 91.73 2.87 6.72 1.65 .001 0.55 0.15 .001

Yes 47 80.63 2.36 91.77 2.26 5.80 1.28 .001 0.43 0.12 .001

No 75 82.58 1.41 91.17 2.80 2.34 0.44 .001 — — — PRI Hydrocephalus .001 .41 .02 Yes 50 82.18 2.51 95.38 2.28 7.23 1.37 .001 0.56 0.13 .001 No 58 90.22 2.15 97.79 2.95 3.24 0.99 .002 0.18 0.09 .045 Mutism .001 .06 .15

No 84 88.50 1.94 98.04 3.29 3.98 0.91 .001 0.21 0.08 .01 WMI

No 81 86.68 1.74 95.58 3.20 3.57 0.85 .001 0.18 0.08 .02 PSI

Yes 23 77.67 3.11 87.93 2.77 5.12 1.57 .002 0.36 0.15 .01

No 57 87.55 2.00 95.17 2.87 2.84 0.92 .003 0.12 0.08 .04 Mutism .001 .02 .39

No 75 88.96 1.71 98.01 3.06 2.36 0.50 .001 — — — VCI Hydrocephalus .009 .50 .09 Yes 50 84.41 2.03 93.21 2.17 4.19 1.23 .001 0.28 0.12 .02 No 57 90.62 1.75 95.10 2.80 1.56 0.91 .09 0.05 0.08 .52 Mutism .02 .01 .87

Total Patients Intercept Slope Quadratic

Yes 43 77.46 1.96 87.47 2.07 2.72 0.65 .001 — — —

No 55 82.28 1.53 89.83 2.65 2.05 0.46 .001 — — — Mutism .003 .004 .91

Yes 45 82.60 2.27 92.86 2.25 2.68 0.72 .001 — — —

Yes 23 74.55 2.36 82.79 2.38 2.24 0.74 .003 — — —

No 54 90.59 1.85 96.61 2.89 1.57 0.54 .005 — — — Mutism .002 .001 .17

Yes 24 83.31 2.92 86.98 2.60 0.96 0.87 .27 — — —

Yes 24 83.10 2.69 87.69 2.25 1.25 0.78 .12 — — — No 83 89.18 1.52 94.33 2.61 1.40 0.45 .002 — — — Abbreviations: FSIQ, Full Scale Intelligence Quotient; PRI, Perceptual Reasoning/Organization Index; PSI, Processing Speed Index; VCI, Verbal Comprehension Index; WMI, Working Memory/Freedom From Distractibility Index. Refers to hydrocephalus requiring treatment to divert cerebrospinal fluid.

Hydrocephalus .16 .38 .40

Hydrocephalus .03 .20 .22

Table 3. Neurologic Complications

FSIQ

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© 2014 by American Society of Clinical Oncology

2015 from 139.18.235.208 Information downloaded from jco.ascopubs.org and provided by at UNIVERSITAETSKLINIKUM LEIPZIG on February 17, Copyright © 2014 American Society of Clinical Oncology. All rights reserved.