paediatrics Brussels 17

Cognitive Abilities After Treatment for Medulloblastoma

Table A2. Final Linear Mixed Effects Models by Neurocognitive Outcome

Outcome and Covariate

Coefficient Estimate

P

Intercept DS

Intercept

18.2232 3.2390 0.9460

.001 .009

Sex (female)

Risk (AR)

.4953 .9253

AgeDx

0.01305 0.8044

Baseline DS

.001

VM

Intercept

17.3422 0.1729 1.9544 0.8078 16.9023 1.9593 0.8275 19.1009 2.8034 0.8359 35.8948 0.4888 0.6472

.001

AgeDx

.1880 .1254

Risk (AR)

Baseline VM

.001

NR

Intercept Risk (AR)

.0003 .1917

Baseline NR

.001

AWM

Intercept Risk (AR)

.001

.0684

Baseline AWM

.001

AA

Intercept Risk (AR)

.001

.7707

Baseline AA

.001

Parent education

0.07832

.7877

PC

Intercept Risk (AR)

6.9547 1.3093 0.9071

.0627 .2586

Baseline PC

.001

Slope DS

Time

4.2792 2.6263 0.3226 0.09653 2.3106 0.08636 0.8310 0.01905

.1899 .0250 .0062

Risk (AR)

time

AgeDx time

Baseline DS time

.001

VM

Time

.2701

AgeDx time

.001

Risk (AR)

time

.0019 .0080

Baseline VM time

NR

Time

11.2763 1.8564 0.1341 8.1587 3.1648 0.1099 5.1546 3.3908 0.1746 0.5637 10.3868 3.0545 0.1383

.001

Risk (AR)

time

.0491

Baseline NR time

.001

AWM

Time

.001 .001 .001

Risk (AR)

time

Baseline AWM time

AA

Time

.2667 .0152

Risk (AR)

time

Baseline AA time

.001

Parent education time

.0182

PC

Time

.0226 .0321

Risk (AR)

time

Baseline PC time .0036 Abbreviations: AA, auditory attention; AgeDx, age at diagnosis; AR, average risk; AWM, auditory working memory; DS, decision speed; NR, numbers reversed; PC, pair cancellation; VM, visual matching.

© 2013 by American Society of Clinical Oncology

www.jco.org

2014 from 139.18.235.210 Information downloaded from jco.ascopubs.org and provided by at UNIVERSITAETSKLINIKUM LEIPZIG on January 15, Copyright © 2013 American Society of Clinical Oncology. All rights reserved.