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Redmond et al.: Radiation to neural progenitor niches and neurocognitive outcomes

at Universitaet Leipzig, Institut fuer Informatik/URZ, Bibliothek on August 25, 2014 http://neuro-oncology.oxfordjournals.org/ Downloaded from

Fig. 3. Performance of patients vs controls at all time points on the Purdue Pegboard 2-Hand (2A), WJ-III Memory for Words (2B), Bead Memory (2C), and visual perception tests (2D). The data represent mean raw scores and SDs. Asterisk (*) indicates significant group differences detected in post-hoc analyses.

Fig. 4. Performance on Purdue Pegboard 2-Hand test ( Z -scores) at 6 mo following completion of RT relative to (A) mean left hippocampal radiation dose, P ¼ .049, and (B) mean right hippocampal radiation dose, P ¼ .032. Standardized scores were used in this analysis to account for the impact of age on test performance.

( P ¼ .067), and left and right hippocampi ( P . .07). There was no difference in performance on this test between left- and right-handed individuals ( P ¼ .52 at 6 mo, P ¼ .89 at 15 mo, and P ¼ .49 at 27 mo). Vocabulary (Peabody Picture Vocabulary Test).— Analyses of vocabulary indicated slight differences in the relationship between the test scores and radiation dose to the right temporal lobe (dose, P ¼ .23; Dose × Visit, P ¼ .024) and left temporal lobe (dose, P ¼ .30; Dose × Visit, P ¼ .058) among visits. The significance of the interaction term Dose × Visit was likely due to a weak relationship between the test scores and radiation doses at visits 3 and 4 ( P ¼ .15 and .18, respectively). There was no association between radiation dose to

P ¼ .033; Dose × Visit, P ¼ .050), no significant rela- tionships were detected at the individual follow-up visits (dose, all P . .10). On verbal learning, there was no significant effect of dose to the left or right hippocam- pus ( P . .24), temporal lobes ( P . .6), or SVZ ( P ¼ .10). Visual perception.— The main analysis of the visual per- ception test indicated an overall tendency for decreased scores with increasing dose to the left temporal lobe (dose, P ¼ .038; Age RT × Dose, P ¼ .041). No significant findings were detected at follow-up visits (dose, all P . .14). There was no significant relationship between performance on visual perception and mean dose to the cerebrum ( P ¼ .062), SVZ ( P . .08), right temporal lobe

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