paediatrics Brussels 17

Evidence for a Developmental Hypothesis for Childhood Cancer Scotting Perilongo & Walker Nature Reviews Cancer (2005) 5; 481-488

• Fidelity of Embryonic / Fetal / Immature

Cell Tissue

microenvironment

• Teratocarcinomas

Mimic many tissues. If transplanted back into growing embryos revert to normal cell behaviour (Martin 1981, Andrews 2002)