paediatrics Brussels 17

No impact of CSI on relapse rate!

Outcome according to RT volume

Author

Outcome after Local RT 31% 5-year PFS

Craniospinal RT 27% 5-year PFS

Goldwein et al 1990

Vanuytsel et al 1992

38% 5-year PFS

46% 5-year PFS

Rousseau et al 1994

40% 5-year EFS

49% 5-year EFS

Stuben et al 1997

58% 5-year PFS

45% 5-year PFS

Mc Laughlin et al 1998

1/17 Leptomeningeal relapses 3/37 Leptomeningeal relapses

0/15 Leptomeningeal relapses 1/10 Leptomeningeal relapses

Oya et al 2002

Pattern of relapse: local relapses predominantly! Merchant et al., 2002: 5/6 relapses occurred locally