paediatrics Brussels 17

Medulloblastoma histology WHO 2016

• There are long-established histological variants of medulloblastoma that have clinical utility (e.g., desmoplastic/nodular, medulloblastoma with extensive nodularity, large cell, and anaplastic)

• It is now widely accepted that there are four molecular genetic groups of medulloblastoma:

WNT-activated, SHH-activated, and the numerically designated “group 3” and “group 4”