paediatrics Brussels 17

Infant (age < 3) Medulloblastoma

• Late effects problematic • Higher risk of M+ disease • Historically poor prognosis • Relatively lower proportion have received a complete resection compared with older children • Generally RT avoidance strategies have resulted in adverse disease control outcomes • GPOH study of chemotherapy alone successful in infants with desmoplastic histology – includes intraventricular methotrexate • Intensive chemotherapy – long-term outcomes not clear • Balance between tumour control and toxicity still unclear • Ongoing clinical trials