paediatrics Brussels 17

Radiotherapy Volume

• French M4 Protocol delivered 2 course of “8 in 1” chemotherapy followed by 2 courses of high-dose methotrexate after surgery • RT was given only to the posterior fossa and spine • Of 16 children, only 3 (18%) were disease-free and alive at mean follow-up of 6 years • Most common site of relapse was supratentorial (9/13 cases)

Bouffet E et al. Int J Radiat Oncol Biol Phys 1992; 24:79-85