paediatrics Brussels 17

A9961: Standard-Risk Medulloblastoma

2340 cGy CSI + posterior fossa boost to total dose of 5580 cGy

Compared two different chemotherapy Regimen: CCNU, CDDP, VCR vs. CDDP, VCR, CPM

5-year EFS is 81% No EFS or overall survival difference Infection more common with CPM Electrolyte abnormality more common with CCNU

Packer RJ et al. J Clin Oncol 2006; 24:4202-8