paediatrics Brussels 17

Hyperfractionated Radiotherapy (HIT-SIOP PNET 4)

340 children (age 4 to 21 years) with standard-risk medulloblastoma randomized to hyperfractionated RT (36 Gy CSI, 60 Gy whole posterior fossa, 68 Gy tumor bed at 1 Gy BID) and conventional RT (23.4 Gy, 54 Gy whole posterior fossa at 1.8 Gy daily) 8 cycles of cisplatin, lomustine and vincristine

Severe hearing loss was not different In the two groups

Lannering B et al. J Clin Oncol 2012; 30:3187-93