paediatrics Brussels 17

Hippocampus

• Composed of the dentate gyrus and cornu ammonis regions • Part of limbic system • Limbic system function: cooperation in learning, consolidation and retrieval of information; essential for formation of new memories • Bilateral and unilateral radiation injury of the hippocampus alters learning and memory formation • Mean doses of >45G to left temporal lobe associated with significant declines in longitudinal IQ