paediatrics Brussels 17

Oncogene Induced Senescence

Excessive MAPK activation induces Irreversible cell cycle arrest by p16 Ink4a /Rb or the p14 Arf /p53 pathway.

Primary cultured pilocytic astrocytoma cells display clear SA-β- Gal activity indicative cell cycle arrest

REPRESENTATION OF MAPK PATHWAY WITH ABERRATIONS Affecting 50-100% of Pilocytic Astrocytomas

MAPK PATHWAY ALTERATIONS ARE UNEVENLY DISTRIBUTED ACROSS BRAIN REGIONS