paediatrics Brussels 17

QoL in adult survivors of childhood brain tumours A population study & A Conceptual Model

Multifactorial late effects model: EJPN (2015) 1e21; Tallen et al: Systematic Literature Review

HRQL deficits in adult survivors. EJC(2009) 2552–2561. Boman et al Case Control Study

• Tumour-related • “Surgical neurotoxicity” • Radiotherapy • Neurocognitive and behavioural impairments • Endocrine deficits • Neuropathies • Neurovascular injury • Sensory deficits • Consequences of chemotherapy • Encephalopathy and neurocognitive decline

• Persistent deficits: cognition, sensory functions, mobility, self-care & overall health • Worse for IGCT, oligos / other glioma, medulloblastoma. • Mild to moderate disability ~ 60% • Education and Independence:: • need for remedial training , • lower educational status • greater reliance on governmental subsidies in adulthood • support as parents

• Premature Ageing • Second Tumours