paediatrics Brussels 17

Alveolar Rhabdomyosarcoma

• Alveolar RMS is associated with characteristic balanced chromosomal translocations t (2; 13) (q35;q14) and t (1;13)(p36;p14) which form a fusion gene between the 5’ end of either PAX3 or PAX7 and the 3’ end of FOXO1 • These alterations are seen in 70 to 80% of ARMS and associated with poor prognosis