paediatrics Brussels 17

Randomized Trial IRS-IV

• No difference in local failure between conventional and hyperfractionated arms • Acute toxicity (mucositis 66% vs. 46% p = 0.03) for parameningeal sites (nausea and vomiting 13% vs. 5% p = 0.02) (skin reactions 16% vs. 7% p = 0.03) and non- parameningeal head and neck sites were increased in hyperfractionated arm • Incidence of local failure (13%) = distant failure (13%) • Standard of care for Group III RMS is conventional radiotherapy with chemotherapy

Donaldson SS et al. Int J Radiat Oncol Biol Phys 2001; 51:718- 28