paediatrics Brussels 17

3-D vs. IMRT in RMS (COG D9803)

IMRT

3-D CRT

Median follow-up

4.2 years

5.7 years

5-year local failure rate

15%

18%

Advantages of IMRT 1. PTV receiving 95% of prescribed dose greater for IMRT 2. Lower mean dose to brainstem with IMRT 3. Both treatment have similar target dose heterogeneity

Lin C et al. Int J Radiat Oncol Biol Phys 2012; 82:1764-70