paediatrics Brussels 17

Delayed Primary Excision and RT Dose Modification

• 161 patients with Group III tumors (bladder dome, extremity, trunk) enrolled on COG D9803 were evaluated • Seventy-three (45%) underwent DPE with removal of all gross disease in 61 (84%) • 43/73 had negative margins and received 36 Gy • 19/73 had microscopic positive margins and received 41.4 Gy • The local 5-year local failure rate were 0% for bladder dome, 7% for extremity and 20% for trunk, similar to IRS-IV which did not encourage DPE

Rodeberg DA et al. Int J Cancer 2015; 137:204-11