paediatrics Brussels 17

COG ARST1431

• Dose escalation to 59.4 Gy for tumors > 5 cm at initial diagnosis • Cone down after 36 Gy is allowable for residual disease • In the case of complete response (CR) by imaging (MRI/CT and PET-CT or negative biopsy), 36 Gy is allowed • In delayed primary excision, dose de-escalation is allowed: 36 Gy for negative margins and 41.4 Gy for positive margins