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MulGfactorial Factors influence tumor control and longterm side effects

Premorbid Conditions

Genetic

Host Factors

Age Gender Race

BRCA, ATM, p53 polymorphisms

Health behavior

Cancer – Related Morbidity

Tumor Factors

Tobacco Diet Alcohol Exercise Sun

Ageing

Histology Site Biology Response

Treatment Factors

Treatment Events

Surgery Chemotherapy Radiation Therapy