paediatrics Brussels 17

SR-VACA arm SR-VAIA arm

HR-EVAIA arm HR-VAIA arm

3y EFS

73%

74%

3y EFS

52%

47%

3y OS

90%

86%

3y OS

62%

59%

In the SR group , the hazard ratios (VACA vs VAIA) for EFS and OS were 0.91 (95% CI, 0.55 to 1.53) and 1.08 (95% CI, 0.58 to 2.03), respectively. There was a higher incidence of hematologic toxicities in the VACA arm. In the HR group , the EFS and OS hazard ratios (EVAIA v VAIA) indicated a 17% reduction in the risk of an event (95% CI, 35% to 5%; P .12) and 15% reduction in dying (95% CI, 34% to 10%), respectively. Cyclophosphamide seemed to have a similar effect on EFS and OS as ifosfamide in SR patients but was associated with increased toxicity. In HR patients, the addition of etoposide seemed to be beneficial