16. Cervix cancer - The GEC-ESTRO Handbook of Brachytherapy

Cervix cancer

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THE GEC ESTRO HANDBOOK OF BRACHYTHERAPY | Part II Clinical Practice Version 1 - 01/09/2023

Adaptive Brachytherapy in Locally Advanced Cervical Cancer: Results From the EMBRACE-I Study. Int J Radiat Oncol Biol Phys. 2023. 79. Kirchheiner K, Pötter R, Nout RA, et al. Late, Persistent, Substantial, Treatment Related Symptoms After Radiation Therapy (LAPERS): A New Method for Longitudinal Analysis of Late Morbidity-Applied in the EMBRACE Study. Int J Radiat Oncol Biol Phys. 2020;106(2):300-9. 80. Vittrup AS, Tanderup K, Bentzen SM, et al. Persistence of Late Substantial Patient Reported Symptoms (LAPERS) After Radiochemotherapy Including Image Guided Adaptive Brachytherapy for Locally Advanced Cervical Cancer: A Report From the EMBRACE Study. Int J Radiat Oncol Biol Phys. 2021;109(1):161-73. 81. Perez CA, Breaux S, Bedwinek JM, et al. Radiation therapy alone in the treatment of carcinoma of the uterine cervix. II. Analysis of complications. Cancer. 1984;54(2):235-46. 82. Cunningham DE, Stryker JA, Velkley DE, et al. Routine clinical estimation of rectal, rectosigmoidal, and bladder doses from intracavitary brachytherapy in the treatment of carcinoma of the cervix. Int J Radiat Oncol Biol Phys. 1981;7(5):653-60. 83. Crook JM, Esche BA, Chaplain G, et al. Dose-volume analysis and the prevention of radiation sequelae in cervical cancer. Radiother Oncol. 1987;8(4):321-32. 84. Perez CA, Grigsby PW, Lockett MA, et al. Radiation therapy morbidity in carcinoma of the uterine cervix: dosimetric and clinical correlation. Int J Radiat Oncol Biol Phys. 1999;44(4):855-66. 85. Koom WS, Sohn DK, Kim JY, et al. Computed tomography-based high-dose rate intracavitary brachytherapy for uterine cervical cancer: preliminary demonstration of correlation between dose-volume parameters and rectal mucosal changes observed by flexible sigmoidoscopy. Int J Radiat Oncol Biol Phys. 2007;68(5):1446-54. 86. Georg P, Lang S, Dimopoulos JC, et al. Dose-volume histogram parameters and late side effects in magnetic resonance image-guided adaptive cervical cancer brachytherapy. Int J Radiat Oncol Biol Phys. 2011;79(2):356-62. 87. Pourquier H, Delard R, Achille E, et al. A quantified approach to the analysis and prevention of urinary complications in radiotherapeutic treatment of cancer of the cervix. Int J Radiat Oncol Biol Phys. 1987;13(7):1025-33. 88. Montana GS, Fowler WC. Carcinoma of the cervix: analysis of bladder and rectal radiation dose and complications. Int J Radiat Oncol Biol Phys. 1989;16(1):95-100. 89. Spampinato S, Fokdal LU, Pötter R, et al. Importance of the ICRU bladder point dose on incidence and persistence of urinary frequency and incontinence in locally advanced cervical cancer: An EMBRACE analysis. Radiother Oncol. 2021;158:300-8. 90. Spampinato S, Fokdal LU, Pötter R, et al. Risk factors and dose-effects for bladder fistula, bleeding and cystitis after radiotherapy with imaged-guided adaptive brachytherapy for cervical cancer: An EMBRACE analysis. Radiother Oncol. 2021;158:312-20. 91. Jensen NBK, Pötter R, Spampinato S, et al. Dose-Volume Effects and Risk Factors for Late Diarrhea in Cervix Cancer Patients After Radiochemotherapy With Image Guided Adaptive Brachytherapy in the EMBRACE I Study. Int J Radiat Oncol Biol Phys. 2021;109(3):688-700. 92. Spampinato S, Jensen NBK, Pötter R, et al. Severity and Persistency of Late Gastrointestinal Morbidity in Locally Advanced Cervical Cancer: Lessons Learned From EMBRACE-I and Implications for the Future. Int J Radiat Oncol Biol Phys. 2022;112(3):681-93. 93. Westerveld H, Kirchheiner K, Nout RA, et al. Dose-effect relationship between vaginal dose points and vaginal stenosis in cervical cancer: An EMBRACE-I sub-study. Radiother Oncol. 2022;168:8-15. 94. Barillot I, Horiot JC, Maingon P, et al. Impact on treatment outcome and late effects of customized treatment planning in cervix carcinomas: baseline results to compare new strategies. Int J Radiat Oncol Biol Phys. 2000;48(1):189-200. 95. Kuske RR, Perez CA, Jacobs AJ, et al. Mini-colpostats in the treatment of carcinoma of the uterine cervix. Int J Radiat Oncol Biol Phys. 1988;14(5):899-906. 96. Tan LT, Jones B, Gee A, et al. An audit of the treatment of carcinoma of the uterine cervix using external beam radiotherapy and a single line source brachytherapy technique. Br J Radiol. 1997;70(840):1259-69.

ACKNOWLEDGMENTS The authors of this chapter are indebted to Alain Gerbaulet and Christine Haie-Meder, authors of the original version of the chapter on cervix cancer in the first edition of the GEC-ESTRO Handbook of Brachytherapy 2002, and to the GEC ESTRO GYN group and the EMBRACE study and research group who have contributed much to the development of the field over the past two decades.

AUTHORS

Li Tee Tan Department of Oncology, Cambridge University Hospitals NHS Trust, Cambridge, United Kingdom Kari Tanderup Department of Oncology, Aarhus University Hospital, Aarhus, Denmark Jacob Lindegaard Department of Oncology, Aarhus University Hospital, Aarhus, Denmark Monica Serban Department of Oncology, Princess Margaret Cancer Centre, Toronto, Canada Remi Nout Department of Radiation Oncology, Erasmus University Medical Center, Rotterdam, the Netherlands Richard Pötter Department of Radiation Oncology, Medical University of Vienna, Vienna, Austria

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