2016_Head & Neck COURSE BOOK

HISTOLOGY

NEW HISTOLOGIC ENTITIES MAMMARY ANALOGUE SECRETORY CARCINOMA Commonest location: parotid gland ETV6-NTRK chromosomal translocation almost every case Differential diagnosis: acinic cell carcinoma High grade transformation: possible CRIBRIFORM ADENOCARCINOMA OF THE TONGUE AND MSGs Only minor salivary glands involved Relatively high risk of nodal metastasis at presentation (60%) Rearrangement of PRKD genes found in more than 80% of the cases Differential diagnosis: polymorphus low grade adenocarcinoma Good prognosis mercoledì 29 giugno 16