2016_Head & Neck COURSE BOOK

Randomized trials with taxanes

Median survival (months)

Regimens

N ORR (%)

218

27%

8.7

Cisplatin/5-FU versus Cisplatin/paclitaxel

26%

8.1

• Cisplatin (100 mg/m2, day 1)/5-FU (1000 mg/m2/d, day 1-4), every 3 weeks • Cisplatin (75 mg/m2, day 1)/paclitaxel (175 mg/m2, day 1), every 3 weeks

Gibson et al JCO 2005