2016_Head & Neck COURSE BOOK

The cancer-immunity cycle

Trafficking of T cells to tumours

Priming and activation (APCs and T cells)

Infiltration of T cells into tumours (CTLs, endothelial cells)

Blood vessel

Lymph node

Cancer antigen presentation (dendritic cells/APCs)

Tumour

Recognition of cancer cells by T cells (CTLs, cancer cells)

CTL = cytotoxic T cell.

Release of cancer cell antigens (cancer cell death)

Killing of cancer cells (immune and cancer cells)

Chen DS, Mellman I. Immunity 2013;39.