2016_Head & Neck COURSE BOOK

evade and suppress the immune system

Inhibition of tumor antigen presentation e.g. down regulation of MHC I 1

APC

Secretion of immunosuppressive factors e.g. TGF-ß 2

Recruitment of immunosuppressive cell types e.g. T-reg 4

Tumor cell

Activated T cell

3

Inhibition of attack by immune cells e.g. through T-cell checkpoint pathways

Inactive T cell

MHC = major histocompatibility complex; TGF-ß = tumor growth factor-ß.

Drake CG, et al. Adv Immunol. 2006;90:51–81; Vesely MD, et al. Annu Rev Immunol . 2011;29:235–271.