2017_SBRT_Course Book

Variability in treatment doses

160

Average Average +/- 1 standard deviation 95% confidence interval

140

120

100

80

60

40

20

Prescribed PTV encompassing dose (BED)

1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 Year 0

Guckenberger JTO 2013

Ø Huge variability in irradiation doses Ø Learning curve with escalation of prescription dose

Matthias Guckenberger - ESTRO SBRT Course 2017

07.09.17

9

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Applicability of LQ model in SBRT: TCP of local tumor control

LQ model

LQ-L model

Ø Clear dose effect relationship in fractionated SBRT Ø LQL-model not statistically superior to LQ model Guckenberger Radiother Oncol 2013

Matthias Guckenberger - ESTRO SBRT Course 2017

07.09.17

10

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