2017_SBRT_Course Book

LQ model versus “extended” biological models

SBRT - stage I NSCLC SRS & SRT - brain mets

Linear quadratic model Linear quadratic linear model Universal Survival Curve Pade Linear Quadratic

Shuryak Radiother Oncol 2015

Ø LQ model sufficient for description of clinical data

Matthias Guckenberger - ESTRO SBRT Course 2017

07.09.17

11

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LQ model versus “extended” biological models

Linear quadratic model Linear quadratic linear model Universal Survival Curve Modified Linear quadratic model Modified Linear quadratic linear model Regrowth model

Liu Radiother Oncol 2017

Ø Significant fit of all models Ø Alpha / Beta ratio of 20Gy, > 10Gy Klement Radiother Oncol 2017 Ø Best fit of regrowth model

Matthias Guckenberger - ESTRO SBRT Course 2017

07.09.17

12

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