207_Combined course Presentations

Progression Free Survival

Definition Time from randomisation to recurrence (in ITT population) Pros • Smaller population and shorter follow-up • Not affected by crossover or subsequent treatment (eg checkpoint inhibitors)

• ? Measure of direct benefit • Subject to assessment bias • Unreliable and imprecise • Blinding required • Need to balance radiological assessments bias – if imbalanced withdrawal of patients who are censored prior to relapse or progression

Cons

Censor