207_Combined course Presentations

Hypoxia-classification: 15-gene hypoxia classifier

• Based on hypoxia induced genes (in vitro/in vivo validated) • Classification based on gene expression similarity to either ”more” or ”less” hypoxic tumours as estimated with pO 2 - electrode in an independent trainingset of 58 H&N cancer patients

100

pO 2 -measurements < 2,5 mmHg

80

60

40

Hypoxic fraction (%) 0 20

0 5 10 15 20 25 30 35 40 45 50 55

Head and neck tumours (n=58)

Less Hypoxic

More Hypoxic

Toustrup K et al, 2011