207_Combined course Presentations

Validating the hypoxia classifier: Independent dataset

414 patients enrolled in the DAHANCA 5 trial

219 randomly assigned to radiotherapy and nimorazole

195 randomly assigned to radiotherapy and placebo

52 excluded from classification (2 failed in PCR, 50 did not have tumour tissue for PCR)

39 excluded from classification (1 failed in PCR, 38 did not have tumour tissue for PCR)

Nimorazole group: 167 for classification Nimorazole group: 167 for classification Placebo group: 156 for classification 323 tumour samples for classification Placebo group: 156 for classification

Classification

(114)

”More” hypoxic

”Less” hypoxic

(209) s” hypoxic (209)

Toustrup K et al, 2012