207_Combined course Presentations
The ’90s… advent of TMZ has changed the paradigm
Oral alkylating agent
Rapidly and completely adsorbed after oral administration
Spontaneous conversion into the active metabolite without the need for liver demethylation (Advantage over dacarbazine)
Excellent penetration into all body tissues, including the brain
Mechanism of resistance to TMZ is mediated through O 6 -methylguanine- DNA methyltransferase ( MGMT ). Many brain tumors express low concentrations of this enzyme .
Newlands ES. et al. Canc Treat Rev 1997;23
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