207_Combined course Presentations
Stupp Regimen: EORTC/NCIC trial – beneficial role of TMZ
Protocol schema
Concurrent TMZ/RT
Adjuvant TMZ
• Median OS: 14.6 vs 12.1 months p < 0.001
R
0
6
10 14 18 22 26 30
Weeks
RT Alone
Temozolomide 75 mg/m 2 po qd for 6 weeks, then 150–200 mg/m 2 po qd d1–5 every 28 days for 6 cycles Focal RT daily — 30 x 2 Gy Total dose 60 Gy
Stupp R. et al. NEJM 2005;352
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