207_Combined course Presentations
Stupp Regimen: major benefit seen in methylated patients
Patients with GBM containing a methylated MGMT promoter benefited from TMZ
Unmethylated patients did not have such a benefit; for these patients alternative treatments with different mechanisms of action or methods of inhibiting MGMT shoulf be investigated
• Can we “somehow” overcome TMZ resistance…?
Hegi M. et al. NEJM 2005;352
Made with FlippingBook