207_Combined course Presentations
Alternative TMZ post-radiation dosing regimens
Regimen
Dose and schedule
Drug exposure
150-200mg/m 2 x 5d q28d
Standard monthly
1
50mg/m 2 /d
Continuous daily
1.8
75mg/m 2 /d x 7d/wk for 6 wk
Continuous (42-49/56-63)
2.1
85-100 mg/m 2 /d x 21d q 28d
Alternating (21/28)
2.6
135-150 mg/m 2 /d x 7d qow
Alternating weekly (7/14)
3.2
200 mg/m 2 (1 st dose), 90-100 mg/m 2 q12h x 9 doses
Twice daily
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