32. Keloids - The GEC-ESTRO Handbook of Brachyterapy

Keloids

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THE GEC ESTRO HANDBOOK OF BRACHYTHERAPY | Part II Clinical Practice Version 1 - 11/04/2025

15. REFERENCES

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1. Mankowski, P., et al., Optimizing Radiotherapy for Keloids: A Meta-Analysis Systematic Review Comparing Recurrence Rates Between Different Radiation Modalities. Ann Plast Surg, 2017. 78(4): p. 403-411. 2. Nast, A., et al., J Dtsch Dermatol Ges, 2021. 19(2): p. 312-327. 3. Escarmant, P., et al., The treatment of 783 keloid scars by iridium 192 interstitial irradiation after surgical excision. Int J Radiat Oncol Biol Phys, 1993. 26(2): p. 245-51. 4. Kovalic, J.J. and C.A. Perez, Radiation therapy following keloidectomy: a 20-year experience. Int J Radiat Oncol Biol Phys, 1989. 17(1): p. 77-80. 5. Goutos, I. and R. Ogawa, Brachytherapy in the adjuvant management of keloid scars: literature review. Scars Burn Heal, 2017. 3: p. 2059513117735483. 6. van Leeuwen, M.C., et al., Surgical Excision with Adjuvant Irradiation for Treatment of Keloid Scars: A Systematic Review. Plast Reconstr Surg Glob Open, 2015. 3(7): p. e440. 7. Brown, J.R. and J.H. Bromberg, Preliminary studies on the effect of time-dose patterns in the treatment of keloids. Radiology, 1963. 80: p. 298-300. 8. Borok, T.L., et al., Role of ionizing irradiation for 393 keloids. Int J Radiat Oncol Biol Phys, 1988. 15(4): p. 865-70. 9. Durosinmi-Etti, F.A., T.A. Olasinde, and E.O. Solarin, A short course postoperative radiotherapy regime for keloid scars in Nigeria. West Afr J Med, 1994. 13(1): p. 17-9. 10. Kal, H.B. and R.E. Veen, Biologically effective doses of postoperative radiotherapy in the prevention of keloids. Dose-effect relationship. Strahlenther Onkol, 2005. 181(11): p. 717-23. 11. Kal, H.B., R.E. Veen, and I.M. Jürgenliemk-Schulz, Dose-effect relationships for recurrence of keloid and pterygium after surgery and radiotherapy. Int J Radiat Oncol Biol Phys, 2009. 74(1): p. 245-51. 12. Anderson, E.M., et al., Interstitial high-dose-rate brachytherapy in the treatment of keloids: Moving toward a volumetric approach. Brachytherapy, 2021. 20(1): p. 185-188. 13. Nicoletis, C. and D. Chassagne, Interstitial irradiation by iridium 192 in the prevention of recurrence after surgical excision of keloid cicatrices. Ann Chir Plast, 1967. 12(3): p. 237-42. 14. Wagner, W., et al., Results of scar keloid prevention using contact irradiation with strontium 90. Rontgenpraxis, 1989. 42(7): p. 248-52. 15. Hafkamp, C.J.H., et al., Postoperative single-dose interstitial high-dose-rate brachytherapy in therapy-resistant keloids. Brachytherapy, 2017. 16(2): p. 415-420. 16. Malaker, A., F. Ellis, and C.H. Paine, Keloid scars: a new method of treatment combining surgery with interstitial radiotherapy. Clin Radiol, 1976. 27(2): p. 179-83. 17. Guix B, F.F., Tello JI, et al., Seven year experience of HDR brachytherapy as treatment of keloids. . Radiother Oncol, 1999. 53: p. abstract 40. 18. Barragán, V.V., et al., Perioperative interstitial high-dose-rate brachytherapy for keloids scar. J Contemp Brachytherapy, 2022. 14(1): p. 29-34. 19. Bijlard, E., et al., Optimal High-Dose-Rate Brachytherapy Fractionation Scheme After Keloid Excision: A Retrospective Multicenter Comparison of Recurrence Rates and Complications. Int J Radiat Oncol Biol Phys, 2018. 100(3): p. 679-686. 20. Manjunath, K.N., et al., Efficacy of Surgical Excision and Adjuvant High-dose Rate Brachytherapy in Treatment of Keloid: Our Experience. J Cutan Aesthet Surg, 2021. 14(3): p. 337-343. 21. Kuribayashi, S., et al., Post-keloidectomy irradiation using high-dose-rate superficial brachytherapy. J Radiat Res, 2011. 52(3): p. 365-8. 22. Fuenmayor, P., et al., Outcomes of Surgical Excision and High-Dose-Rate Brachytherapy for Earlobe Keloids. World J Plast Surg, 2021. 10(1): p. 78-84. 23. Bautista Hernandez, Y., et al., Surface brachytherapy in the treatment of keloid scars in Mexico. Rep Pract Oncol Radiother, 2020. 25(1): p. 133-138. 24. Bhattacharya, N., K. Bhattacharya, and T.C. Chandran, Treatment of Keloids with Surgery and Immediate Postoperative Radiotherapy: Knowledge Gained Over 17 Years. Indian J Plast Surg, 2023. 56(3): p. 251-259.

ACKNOWLEDGMENTS The authors of this chapter are much indebted to Alain Gerbaulet, author of the original version of the chapter on Keloids in the first edition of the GEC ESTRO Handbook of Brachytherapy 2002.

AUTHORS

Peter Niehoff Department of Radiotherapy Sana Klinikumn Offenbach Germany

Erik Van Limbergen Department of Radiation Oncology University Hospital Gasthuisberg Leuven Belgium