ESTRO 2020 Abstract book

S729 ESTRO 2020

2000 consecutive patients (pts) of RT Dept will be enrolled and data on gender, age, presence/absence of pain, intensity of pain (measured with Numeric Rating Scale-NRS and pain score), type of pain (cancer pain-CP, noncancer pain-NCP, mixed pain- MP), prescribed analgesics (analgesic score), aim of RT treatment, ECOG Performance Status (PS) will be collected. Pain score and analgesic score are evaluated as shown in Table 1. PMI is calculated by subtracting the pain score from the analgesic score. A negative value of PMI indicates an inadequate analgesic prescription.

Conclusion the characteristics of pts receiving the most inadequate analgesics prescription are opposite to those of the pts with the most severe pain, suggesting that a negative PMI is not related to a higher pain score but rather to an inadequate management of pain by the physician, whereas Radiation Oncologists approach when prescribing analgesics should not be negatively influenced by the more favourable characteristics of pts. However, it’s remarkable that the pain management in critical pts is accurate. PO-1292 Radiation planning parameters correlate with peripheral immune status during prostate radiotherapy F. Eckert 1 , B. Frey 2 , D. Zips 1 , C. Gani 1 , H. Rammensee 3 , C. Gouttefangeas 3 1 University Hospital Tübingen, Radiation Oncology, Tübingen, Germany ; 2 University Hospital Tübingen, Biomedical physics, Tübingen, Germany ; 3 University of Tübingen, Interfaculty Institute for Cell Biology- Department of Immunology, Tübingen, Germany Purpose or Objective With the rise of immunotherapy-radiotherapy combinations it is crucial to understand immune changes during and following radiotherapy. In a non-interventional clinical trial, detailed immune phenotyping of peripheral blood mononuclear cells (PBMCs) revealed significant immune changes during normofractionated, curative radiotherapy for prostate cancer (in most patients combined with androgen deprivation therapy (ADT)). The aim of this exploratory analysis was to investigate possible correlations of radiotherapy volumes and dose parameters with immune changes found during radiotherapy. Material and Methods For all 18 patients (13 with radiotherapy to prostate only and 5 with radiotherapy to the prostate and pelvic nodal regions) volume parameters (CTV, PTV) and dose parameters were recorded for initially contoured volumes

Results Table 2 shows the characteristics of the first 626 pts enrolled in 7 RT Dept. Of these, 73.2% (458 pts) had pain (Table 3): in 51.3% cases it was CP, 31% was NCP, 17.7% was MP. PMI was <0 in 47.6% of pts. MP is related to higher NRS than CP e NCP (p = 0.002). NCP is related to lower analgesic score values (50% of these pts had analgesic score = 0) than CP and MP (p < 0.001). Pts with CP and MP had more adequate analgesics prescription than NCP pts (p < 0.001). An increasing in NRS is related to a worse PS in all the pts categories. In pts with CP and NCP a worse PS is related with better PMI value (p < 0.001 and p = 0.002, respectively). At the univariate analysis, higher pain intensity measured with NRS is typical of pts with metastatic disease (p = 0.002), pts receiving palliative RT treatment (p < 0.001), and pts with poor PS (p < 0.001). The lower adequacy of analgesic prescription (PMI<0) is typical of women (p = 0.006), pts with no metastatic disease (p < 0.001), pts receiving curative RT treatment (p < 0.001) and pts with good PS (p < 0.001).