Advanced TP

The Volume Effect in OAR

n   

Parallel

V

  

(

)

(

)

reference

VD

VD

=

⋅

irradiated

reference

V

irradiated

Relative Tolerance Dose

20

10

5

1

0.1

0.5

0.5

1/ n a =

Fraction of Irradiated Volume

Serial

0

1

Adapted and redrawn from: Marks LB, et al. Use of normal tissue complication probability models in the clinic. Int. J. Radiat. Oncol. Biol. Phys. 2010 (76-3): S10-S19.