Advanced TP

The Volume Effect in OAR

n   

V

  

(

)

(

)

reference

VD

VD

=

⋅

irradiated

reference

V

irradiated

1. n value is function of the structure: Lung Spine 2. Within a structure n can be function of the effect: Proctitis (Rectum) Dementia (Brain) Rectal Bleeding (Rectum) Necrosis (Brain) 3. Within a structure n can be function of the anatomy

Marks LB, et al. Use of normal tissue complication probability models in the clinic. Int. J. Radiat. Oncol. Biol. Phys. 2010 (76-3): S10-S19.