Advanced TP

Clinical evaluation: comparison of toxicity data from different protocols • Biologically Effective Dose  A parameter that is independent from the fractionation  It doesn’t express a real delivered dose

/

/

D D

d

1 D BED

d

+

α α

β β

+

α /

β

=

=

1 2

2 1

1

2

1

/

0

d

+

+

α

β

d D BED

d dN

  

  

 

  

1

1

⋅ =

+

=

+

1

1

3

1

1

/

/

α

β

α

β

α/β : alfa-beta ratio

N : fraction number d 1 : fraction number

for the given effect