Advanced TP

Parameters for clinical outcome: Brain Endpoint: Symptomatic necrosis vs Asymptomatic necrosis

• 129 patients with 198 separate non-AVM • Radiosurgery technique (gamma-knife) • Median prescribed max dose 34.6 Gy (range 22 Gy – 50 Gy) • Logistic regression

V12 Gy WBRT

p = 0.007 p = 0.03 p = 0.0001

Occipital and temporal location

Male sex

p = 0.03

S-NEC [%]

S-NEC Probability

V 12 Gy [ cc ]

V 12 Gy [ cc ] T Korytko et al. 12 Gy gamma knife radiosurgical volume is a predictor for radiation necrosis in non-AVM intracranial tumors. Int. J. Radiation Oncology Biol. Phys., Vol. 64, No. 2, pp. 419–424, 2006