BCRB 2018

19/09/2018

Relevant factors

• Radiobiology -related factors influencing normal tissue reactions • Intrinsic radiosensitivity • Total radiation dose • Technique and irradiated volume

• Fractionation schedule (late reactions) • Overall treatment time (early reactions) • Concomitant treatment

27

Relevant radiobiology factors

26 patients derived fibroblasts Hierarchical clustering 3 x 3.5 Gy

• Intrinsic radiosensitivity

Sensitive profile

Alsner J Radiother Oncol 2007 26 pts

Resistant profile

Differential gene expression in irradiated fibroblasts between pts with variable risk of radiation-induced fibrosis

28