BCRB 2018

19/09/2018

Relevant factors

• Radiobiology -related factors influencing normal tissue reactions • Intrinsic radiosensitivity • Total radiation dose • Technique and irradiated volume

• Fractionation schedule (late reactions) • Overall treatment time (early reactions) • Concomitant treatment

29

Relevant radiobiology factors

• Total radiation dose

Average MLD 10.3±5.6Gy MLD Pts with RP12.5±4.3Gy > MLD pts without RP MLD 9.9±5.8Gy

Dose-response relationship for radiation-induced pneumonitis (RP) after pulmonary stereotactic body radiotherapy

59 patients

30

Guckenberger Radiother Oncol 2010 59 pts