BCRB 2018

100

Parameters chosen to make response similar to LQ at low doses

Two-component model may also better describe

n

10

D q

response to high-dose fractions

1

exp(– D / D 1 )

0.1

Surviving fraction

0.01

High LET

(

) n

⎛ ⎝⎜

0 ⎞ ⎠⎟

D 0

(

)

1 − 1 − e − D 1 D 0

− 1 D 1

0.001

S = e − D D 1

4

8

12

16

Radiation dose (Gy)

Michael Joiner

Basic Clinical Radiobiology 2018

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