BCRB 2018

0.5 0.6 0.7 0.8 0.9 1

Low-dose hyper- radiosensitivity

T98G human GBM cells

D c

α r

Short S, Mayes C, Woodcock M, Johns H, Joiner MC. Int J Radiat Biol 1999;75:847–55.

α s

0.4

S = e − α D − β D 2 α = α r 1 + α s (

Surviving fraction

(

)

) e − D D c

0.3

α r

− 1

First reported in 1986 in mouse epidermis and kidney

0.2

0

1

2

3

4

5

6

Dose/Gy

Michael Joiner

Basic Clinical Radiobiology 2018

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