BCRB 2018
19/09/2018
Tumor regression ≠ cell survival
Human s.c.c. xenograft treated with 8 X 3 Gy / 4 wks
control drug X XRT drug + XRT
Tumor removed
drug X = VEGFR2 inhibitor
Regrowth delay assay
• Comparison of growth curves of treated and untreated tumors gives the delay caused by treatment • Relationship between growth delay and surviving fraction of stem cells is complex • Regrowing cells have different environment: surrounded by dead and dying cells; vascular network is already in place
Growth Kinetics of Tumors, G.G. Steel, 1977
• Tumor bed effect
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