BCRB 2018

Dose fractionation: LQ formalism

a/b -value - early effects / experimental data

Ref.

a/b -value [Gy] -

Tissue/reaction

Epidermis

Desquamation

Douglas and Fowler 1976 Joiner et al. 1983 Moulder and Fischer 1976 Ruifrok et al. 1994

9.1-12.5 8.6-10.6 9-12 49.6 [42.2;58.6] 7.9 [1.8;25.8] 10.8 7.4 16.4 [14.6;18.2] 11.6 [6.8;18.9] 11.9 [7.4;20.2]

Oral mucosa

Ulceration

Ang et al. 1985 Moses and Kummermehr 1986 (Reanalysis)

Scalliet et al. 1987 Stüben et al. 1991 Dörr et al. 1993 Nickstadt and Dörr, unpublished

Intestine

Crypt survival

Withers et a. 1976 Thames et al. 1981 Tucker et al. 1983

6.0-8.3 6.6-10.7 8-9 13.3 9-13-

Huczkowski and Trott 1984 Tucker and Denekamp 1984 Dörr and Schultz-Hector 1992 Dörr 1995

Weight loss

Urinary bladder Impaired function

13.9 [8.4;24.6] 11.0 [7.5;16.1]

Testis

clon. survival

Thames and Withers 1980

12-13

ESTRO BCR Course / NT radiosensitivity and fractionation – W. Dörr