BCRB 2018

Dose fractionation: LQ formalism

a/b -value - late effects / experimental data Tissue / reaction a/b -value [Gy] Ref.

van der Kogel 1979

Spinal cord

1.8-2.7 1.6-1.9 1.5-2.0 2.2-3.0 3.7-4.5 4.1-4.9 3.8-4.1 2.3-2.9 3.1-5.0 1.7-2.0 1.7-2.0 0.5-3.8 1.0 0.9-2.8 1.4-4.3

cervical

White and Hornsey 1978

Ang et al. 1983 Thames et al. 1981

lumbar

van der Kogel 1979 White and Hornsey 1978

Leith et al 1981

Amals and Yuhas

Weight loss

Terry and Denekamp

Intestine

Rectal stenosis

Trott and Kummermehr 1994

Caldwell 1975

Kidney

Hopewell and Wiernik 1977

van Rongen et al. 1988

liams and Denekamp 1984

Stewart et al. 1984 Thames et al. 1988 Stewart et al. 1984 Bentzen et al. 1992

Urinary bladder Impaired function

6.6 [2.2;14.5] 5.8 [3.6;8.8] 4.4 [2.0;8.4]

Dörr and Bentzen 1999

LD50

Wara et al. 1973

Lung

4.4-6.3 2.8-4.8 2.0-2.4 1.9-3.1

Field et al 1976

Travis et al. 1983

Breathing frequency

Parkins and Fowler 1985

ESTRO BCR Course / NT radiosensitivity and fractionation – W. Dörr